Shortcomings of the Grave Breaches Regime by Dieter Fleck
By Dieter Fleck
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Gastrointestinal symptoms in diabetic patients: lack of association with neuropathy. Am J Gastroenterol 1989; 84: 868–72. 18. Ko GT, Chan WB, Chan JC, Tsang LW, Cockram CS. Gastrointestinal symptoms in Chinese patients with type 2 diabetes mellitus. Diabet Med 1999; 16: 670–74. 19. Maxton DG, Whorwell PJ. Functional bowel symptoms in diabetes—the role of autonomic neuropathy. Postgrad Med J 1991; 67: 991–3. 20. Dandona P, Fonseca V, Mier A, Beckett AG. Diarrhea and metformin in a diabetic clinic.
Most studies performed in animal models of insulin resistance and type 2 diabetes report an acceleration of gastric emptying. 2 Fraction of phenol red tracer recoverable from the stomach of BB (autoimmune type 1 diabetic) rats compared to Harlan Sprague–Dawley (non-diabetic) rats 20 min after gavage with an acaloric gel 38 GASTROINTESTINAL FUNCTION IN ANIMAL MODELS of type 2 diabetes [60], the LA/N corpulent rat [61] and a hyperphagic model [62] exhibited accelerated emptying. Thus, gastric emptying appears accelerated in hyperphagic, insulin-resistant rats and in most insulinopenic rodent models.
Gastrointestinal complications of diabetes mellitus. Clin Gastroenterol 1983; 2: 633–50. 6. Yang R, Arem R, Chan L. Gastrointestinal tract complications of diabetes mellitus. Arch Intern Med 1984; 144: 1251–6. 7. Niakan E, Harati Y, Comstock JP. Diabetic autonomic neuropathy. Metabolism 1986; 35: 224–34. 8. Nompleggi D, Bell SJ, Blackburn GL, Bistrian BR. Overview of gastrointestinal disorders due to diabetes mellitus: emphasis on nutritional support. J Parent Ent Nutr 1989; 13: 84–91. 9. Rothstein RD.


