Protein Crosslinking: Nutritional and Medical Consequences by Mendel Friedman (auth.), Mendel Friedman (eds.)
By Mendel Friedman (auth.), Mendel Friedman (eds.)
The observe crosslinking implies sturdy mix of often huge, detailed components at particular locations to create a brand new entity that has various houses as a result of union. in terms of proteins, such crosslinking frequently leads to vital adjustments in chemical, actual, useful, dietary, and biome dical houses, along with actual homes easily on the topic of molecular dimension and form. (Nucleic acids, carbohydrates~ glyco proteins, and different biopolymers are correspondingly affected.) for the reason that proteins are ubiquitous, the implications in their crosslin king are frequent and sometimes profound. Scientists from many dis ciplines together with natural chemistry, biochemistry, protein chemis try out, foodstuff technology, nutrients, radiation biology, pharmacology, body structure, medication, and dentistry are, accordingly, greatly inte rested in protein crosslinking reactions and their implications. simply because protein crosslinking encompasses such a lot of disciplines, in organizing the Symposium on dietary and Biochemical results of Protein Crosslinking backed through the Protein Subdivision of the department of Agricultural and nutrients Chemistry of the yankee Chemical Society, I sought individuals with the broadest attainable variety of pursuits, but with a typical quandary for theoretical and sensible facets of protein crosslinking. an enormous functionality of a symposium is to catalyze development by way of bringing jointly principles and stories wanted for interplay between various, but comparable disciplines. To my friendly surprize, approximately everone invited got here to San Francisco to participate.
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Friedman, M. and Wall, J. S. (1964). llfX>unds with acrylonitrile. ~· Am. Chern. 26 M. , 86, 3735-3741. , III and O'Leary, M. H. (1975). Modification of arginine and lysine in proteins with 2,4-pentanedione. Biochemistry, 14, 5194-5198. Ginsburg, S. and Wilson, I. B. (1964). Factors affecting the competitive formation of oxazolines and dehydroalanines from serine derivatives. J. Am. Chern. , 86, 4716-4720. Gould, D. G. ---ci977). Nutritional and biological consequences of protein crosslinking: an overview.
L. Loening, J. R. Whitaker, for their constructive comments and contributions to this manuscript, and Amy T. Noma and Linda c. Loyd for the amino acid analyses. REFERENCES Alworth, W. L. (1976). Private connnunication. Alworth, w. L. (1972). "Steroechemistry and Its Application in Biochemistry," Wiley, Inter science, New York. Asquith, R. s. and Otterburn, M. S. (1977). Cystine-alkali reactions in relation to protein crosslinking. This volume. Bentley, R. B. (1970) • "Molecular Asynunetry in Biology," Volume II, Academic Press, New York.
3-Methyl-3-tyrosin-o4-yl alanine (MeTyAL) Q4-[(1R,2R)-2-amino-2-carb oxy-l-methylethyl]-g-tyro sine CROSSLINKING AMINO ACIDS 9_4- ElR,2S)-2-amino-2-carboxy-l-methylethy~ -~tyrosine Q4- IT lS, 2S) -2-amino-2-carboxy-1-methylethyl] -If-tyrosine 9_4- ElS,2R)-2-amino-2-carboxy-l-methylethy~ -¥-tyrosine 19 o. Arginine Derivatives Some arginine residues in proteins may be degraded to ornithine under alkaline conditions (Gilbert and O'Leary, 1975). The amino group of ornithine could then react with dehydroalanine as mentioned earlier.



