Medical and Surgical Management of Tachyarrhythmias by Wolfgang Bircks M. D., Franz Loogen M. D. (auth.), Wolfgang
By Wolfgang Bircks M. D., Franz Loogen M. D. (auth.), Wolfgang Bircks M. D., Franz Loogen M. D., Hagen D. Schulte M. D., Ludger Seipel M. D. (eds.)
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Extra info for Medical and Surgical Management of Tachyarrhythmias
Example text
Electrophysiologic studies similar to those presented in Fig. 1 have not been reported in man. However, supportive evidence that these accelerated idioventricular arrhythmias in man result from Purkinje fiber activity has been obtained by Friedman et al. By using ultrastructural techniques (42,49), these investigators have demonstrated that human subendocardial Purkinje fibers also remain structurally intact for 16 to 30 h in areas of myocardial infarction at a time when adjacent ventricular muscle cells are undergoing degeneration, and therefore could be involved in ventricular tachyarrhythmias.
We found that aprindine concentrations in the normal zone at all times measured after coronary artery occlusion were similar in all groups of animals. In group 1 animals, ischemic zone aprindine concentrations decreased more slowly than normal or border zone aprindine concentrations and significantly exceeded normal zone concentrations 70 min after coronary artery occlusion. In contrast, ischemic zone aprindine concentrations in group 2 dogs were initially significantly lower than border and normal zone aprindine concentrations.
Michelson EL, Spear JF, Moore EN (1979) Sustained reentrant ventricular tachyarrhythmias. Electrophysiologic and anatomic correlates in a model of chronic ischemia. Clin Res 27:188A 59. Michelson EL, Spear JF, Moore EN (1979) The anatomic basis for sustained reentrant ventricular tachyarrhythmias in a model of chronic ischemia. Clin Res 27:188A 60. Spielman SR, Farshidi A, Horowitz LN, Josephson ME (1978) Ventricular fibrillation during programmed ventricular stimulation. Incidence and clinical implications.