Brain Protection in Schizophrenia, Mood and Cognitive by Ehud Susser, Michael S. Ritsner MD, PhD. (auth.), Michael S.

Brain Protection in Schizophrenia, Mood and Cognitive by Ehud Susser, Michael S. Ritsner MD, PhD. (auth.), Michael S.

By Ehud Susser, Michael S. Ritsner MD, PhD. (auth.), Michael S. Ritsner (eds.)

Neuroprotection is a singular viewpoint for the therapy of issues that bring about neurodegeneration and disabilities because of deterioration of neurons because of apoptosis, oxidative rigidity, excitotoxicity, and different mechanisms. those mechanisms have implications not just for neurodegenerative problems, but additionally for schizophrenia, temper and cognitive problems. the aim of this booklet isto supply an updated evaluate of uncomplicated and scientific experiences in regards to the neuroprotective procedure, mechanisms, and a number of other compounds with neuroprotective homes that could give a contribution to extra efficacious therapy of significant psychological healthiness issues. The ebook is split into sections. the 1st part serves as an advent and assessment of conceptual problems with the neuroprotective method, and some neurobiological advances. Chapters during this part overview definitions, views, and matters that offer a conceptual base for the remainder of the e-book. moreover, this half contains chapters during which the authors current and speak about the findings from easy reviews of neurodegenerative mechanisms which are linked to the pathogenesis of significant psychological future health problems. the second one part specializes in findings got from medical trials with neuroprotective compounds, and neuromodulatory suggestions. The take-home message is that rules of the neuroprotective strategy could be utilized to remedy of schizophrenia, temper and cognitive problems. individuals to this publication are one of the such a lot energetic investigators and clinicians within the box who offer new views not just clarifying ongoing controversies but in addition suggest diversified points and new insights to neuroprotection. This e-book is meant for a wide readership, which incorporates a vast spectrum of readers together with neuroscientists, psychiatrists, neurologists, pharmacologists, medical psychologists, normal practitioners, geriatricians, graduate scholars, and coverage makers within the fields of psychological health.

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Extra resources for Brain Protection in Schizophrenia, Mood and Cognitive Disorders

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Am J Psychiatry 2000 January; 157:16–25 1 Brain Protection in Neuropsychiatric Disorders 23 50. Cahn W, Rais M, Stigter FP et al. Psychosis and brain volume changes during the first five years of schizophrenia. Eur Neuropsychopharmacol 2009 February; 19:147–151 51. Hulshoff Pol HE, Kahn RS. What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia. Schizophr Bull 2008 March; 34:354–366 52. Goodwin GM, Martinez-Aran A, Glahn DC et al.

Neurology 2009 February 17; 72:S59–S64 25. Stangel M. Neuroprotection and neuroregeneration in multiple sclerosis. J Neurol 2008 December; 255(Suppl 6):77–81 26. Miller RG, Mitchell JD, Lyon M et al. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev 2007; CD001447 27. Brooks BR. Managing amyotrophic lateral sclerosis: slowing disease progression and improving patient quality of life. Ann Neurol 2009 January; 65(Suppl 1):S17–S23 28. Stip E, Chouinard S, Boulay LJ.

Blocking these pathogenic pathways is the aim of neuroprotective treatments. 1) and have many similarities to various CNS diseases. Thus, in stroke, there are excitotoxicity, oxidative stress, inflammation and apoptotic-like processes. In neurodegenerative disorders, we have excitotoxicity, inflammation, apoptotic-like processes and protein misfolding. Excitotoxicity, inflammation and apoptosis-like processes represent the backbone common to most neuropathologies. Controlling these processes is the key to efficient neuroprotection in all neurological disorders.

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