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Extra resources for Black's Medical Dictionary
In the young, severe injury is the most common cause, when damage to the limb is so extensive as to make it non-viable or functionally useless. In the elderly, amputation is more often the result of vascular insuﬃciency, resulting in gangrene or intractable pain. A group of drugs closely related to ADRENALINE which act by stimulating the SYMPATHETIC NERVOUS SYSTEM. When taken by mouth they have a profound stimulating eﬀect on the brain, producing a sense of well-being and conﬁdence and seemingly increasing the capacity for mental work.
CORTICOSTEROIDS give temporary relief. Fibrosing alveolitis In this disease there is diﬀuse FIBROSIS of the walls of the alveoli of the lungs. This causes loss of lung volume with both forced expiratory volume and vital capacity aﬀected, but the ratio between them remaining normal. The patient complains of cough and progressive DYSPNOEA. Typically the patient will be cyanosed (blue – see CYANOSIS), clubbed (see CLUBBING), and have crackles in the mid- and lower-lung ﬁelds. Blood gases will reveal HYPOXIA and, in early disease, hypocapnia (deﬁciency of carbon dioxide in the blood due to hyperventilation).
Most allergic disorders are linked to ATOPY, the predisposition to generate the allergic antibody immunoglobulin E (IgE) to common environmental agents (see ANTIBODIES; IMMUNOGLOBULINS). Because IgE is able to sensitise MAST CELLS (which play a part in inﬂammatory and allergic reactions) anywhere in the body, atopic individuals often have disease in more than one organ. Since the allergic disorder HAY FEVER was ﬁrst described in 1819, allergy has moved from being a rare condition to one aﬄicting almost one in two people in the developed world, with substances such as grass and tree pollen, house-dust mite, bee and wasp venom, egg and milk proteins, peanuts, antibiotics, and other airborne environmental pollutants among the triggering factors.