Textbook of Contact Dermatitis by Jean-Marie Lachapelle (auth.), Dr. Richard J. G. Rycroft,
By Jean-Marie Lachapelle (auth.), Dr. Richard J. G. Rycroft, Prof. Dr. med. Torkil Menné, Prof. Dr. med. Peter J. Frosch (eds.)
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Ones that do not cause a severe skin reaction on short contact « 1 h). The resulting skin lesion may vary with the type of exposure, body region and individual susceptibility (Fig. 9). 2. Common irritants which are important causes of occupational dermatitis (adapted from [14, 28, 91]) Water and its additives (salts and oxides of calcium, magnesium. and iron) Skin cleansers Soaps. detergents, 'waterless cleansers' and additives (sand, silica) Industrial cleaning agents Detergents, surface-active agents, sulphonated oils, wetting agents, emulsifiers, enzymes Alkalis Soap, soda, ammonia, potassium and sodium hydroxides, cement, lime, sodium silicate, trisodium phosphate, and various amines Acids Severe irritancy (caustic): sulphuric, hydrochloric, nitric, chromic.
Malten et al. used the term 'delayed irritation' for this type of cutaneous irritancy. Delayed irritation may be more common than generally thought so far. Further substances causing it include benzalkonium chloride, dithranol and tretinoin. Irritant patch test reactions to benzalkonium chloride may be papular and increase in intensity with time [11,13]. On the normal skin surrounding psoriatic plaques, dithranol causes redness and edema, which may become very severe on the legs due to venous stasis.
1985) Penicillin allergy and desensitization in serious infections during pergnancy. N Engl J Med 312: 1229-1232 70. Polak L, Rinck C (1978) Mechanism of desensitization in DNCB-contact sensitive guinea pigs. J Invest Dermatol 70: 98-104 71. Gaspari AA, Jenkins MK, Katz SI (1988) Class II MCH-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific THI clones. J Immunol 141: 2216-2220 72. Boerrigter GH, Scheper RJ (1987) Local and systemic desensitization induced by repeated epicutaneous hapten application.