Harper's Textbook of Pediatric Dermatology, Volume 1, 2,
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Extra resources for Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition
Example text
39 Holbrook KA, Wolff K. The structure and development of skin. In: Fitzpatrick TB, Eisen AZ, Wolff K et al. (eds) Dermatology in General Medicine, 6th edn. New York: McGraw-Hill, 1993: 97–144. 40 Holbrook KA, Sybert VP. Basic science. In: Schachner L, Hansen R (eds) Pediatric Dermatology, 2nd edn. New York: Churchill Livingstone, 1995. 41 Smith LT, Holbrook KA, Byers PH. Structure of the dermal matrix during development and in the adult. J Invest Dermatol 1982;79:93S–104S. 42 Smith LT, Holbrook KA.
Studies of skin development can also shed light on a number of basic problems in contemporary biology: epithelial–mesenchymal interactions that establish organs (in skin, these tissue interactions occur in follicle, sweat gland and nail formation); cell–cell interactions through soluble mediators; gene regulation; apoptosis; differentiation (structural, biochemical and functional); and certain longstanding basic phenomena of development such as induction, pattern formation and differentiation. They provide an opportunity to ask how a molecule is expressed and how expression of that molecule may modify the properties of the tissue over a time sequence that begins in the simple embryonic environment and builds progressively to more complex fetal conditions.
Dopa reaction of fetal melanocytes before and after skin transplantation onto nude mice. Br J Dermatol 1995;133:884–9. 11 Oliver AM. The cytokeratin expression of cultured human foetal keratinocytes. Br J Dermatol 1990;123:707–16. 12 Scott G, Ewing J, Ryan D et al. Stem cell factor regulates human melanocyte–matrix interactions. Pigment Cell Res 1994;7: 44–51. 13 Holbrook KA, Smith LT, Elias S. Prenatal diagnosis of genetic skin disease using fetal skin biopsy samples. Arch Dermatol 1993;129:1437–54.