Epilepsy and the Ketogenic Diet by Carl E. Stafstrom (auth.), Carl E. Stafstrom MD, PhD, Jong
By Carl E. Stafstrom (auth.), Carl E. Stafstrom MD, PhD, Jong M. Rho MD (eds.)
Recent advances in our knowing of the ketogenic nutrition (KD)-a high-fat, low-carbohydrate, adequate-protein vitamin used for the remedy of medically intractable epilepsy-have produced a resurgence of curiosity in, and alertness of, this important therapy for the epileptic sufferer. In Epilepsy and the Ketogenic nutrition, the world over well-known researchers and clinicians from worldwide synthesize the present nation of the technology and medical perform of the KD. at the simple technological know-how facet, the authors evaluate what's identified concerning the uncomplicated biochemical mechanisms of motion of the KD on the molecular point, spelling out intimately its complicated interactions with nutrient parts, neurodevelopment, mind biochemistry, and body structure. in addition they learn the consequences of the KD at the metabolism of fat, amino acids, and carbohydrates within the significant fearful procedure at either the macro and mobile degrees. at the scientific aspect, physicians, dietitians, and nurses supply an entire variety of knowledge in regards to the remedy of seizures with KD, together with a close evaluate of the symptoms for, and the contraindications and/or problems that come up from its use, certain equations that let the caregiver to calculate the particular quantities of other sorts of meals that may be integrated in day-by-day nutrition plans, and documented details at the carbohydrate and calorie content material of 1000's of popular medications. a variety of appropriate tables, graphs, and figures, in addition to updated references, constant use of phrases throughout chapters, and a hugely annotated index make sure quick access to wanted information.
Illuminating and hugely sensible, Epilepsy and the Ketogenic vitamin constitutes a special benchmark synthesis of updated medical and medical info that explains the mechanisms in the back of the KD and the way its greatest healing merits will be learned within the epileptic sufferer with minimum adversarial effects.
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Extra resources for Epilepsy and the Ketogenic Diet
Example text
Stanley Cobb of Harvard was in the audience that day and commented that he had experimentally used starvation to prevent convulsions in an animal model. At that time, Cobb did not know that the father of the first child Geyelin had discussed would come to him in 1922 and ask him to explain the mechanism of action of starvation in treating epilepsy; we pick up this thread of the story again later in this section. At this time, Dr. Conklin believed that epilepsy, which he labeled "intestinal epilepsy," had its origin in the intestines and was curable ( 13 ).
Depending on which of hilar neurons are silenced (by seizure-induced cell death) or activated by seizure activity, the physiology of the circuit could be vastly altered (39). This synaptic flexibility is an example of seizure-induced plasticity and can give rise to complicated circuits that can either compensate for or exacerbate the initial seizure situation. Chapter 1 I Seizures and Epilepsy 23 To make matters even more complicated, seizures can induce neurogenesis in certain areas of the brain, that is, the birth of new neurons (even in the adult brain).
Modified with permission of the American Academy of Pediatrics from ref. ) Neuronal Network 8 Brain A Chapter 1 I Seizures and Epilepsy 19 huge number of neurons is firing synchronously, the result of which would be a clinical seizure with manifestations correlating with the area of brain involved. 2. Pathophysiological Events in Neuronal Network What is happening at the neuronal network level when neurons transition from their normal firing pattern to the interictal condition and then to the ictal state?