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It is a 3-in-1 reference booklet. It provides an entire scientific dictionary masking enormous quantities of phrases and expressions when it comes to ldl cholesterol. It additionally offers vast lists of bibliographic citations. eventually, it offers details to clients on tips on how to replace their wisdom utilizing a number of net assets. The ebook is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to familiarize yourself with learn devoted to ldl cholesterol. in case your time is efficacious, this ebook is for you. First, you won't waste time looking out the net whereas lacking loads of suitable details. moment, the e-book additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing hundreds of thousands of web content.
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Additional resources for Cholesterol - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
The second project involves a study of the functions of apolipoprotein A-I in mediating cholesterol transport at cell surfaces. The molecular mechanisms by which apo A-I removes and delivers cholesterol, cholesteryl ester and phospholipid from and to cell plasma membranes will be investigated. The last project focuses on the metabolism of cholesterol in model foam cells. Emphasis is placed on the structure of cholesteryl ester cytoplasmic droplets, characterization of the enzymes involved in their metabolism, and the consequences for macrophages of over-accumulation of unesterified cholesterol.
The application proposes to test the following hypotheses: 1that in the human brain increased cholesterol content contributes to amyloid accumulation by changing APP processing in a more amyloidogenic manner. 2-that there are correlative interactions between levels of apoE expression, cholesterolemia and amyloid pathology. 3-that certain apoE promoter polymorphisms act in concert with cholesterol levels influencing the extent of apoE expression and amyloid accumulation. Preliminary and recently published data from our laboratory suggest that cholesterol content in plasma and brain of Alzheimer's transgenic mice is strongly correlated with rate of development of amyloid pathology and with apoE expression.
All tissue/cell models described are available in this laboratory. Currently used technologies permit us to faithfully track proteins both biochemically and morphologically, and the integrated system we propose to study should yield detailed information on potential protein links between the SR-BI receptor and the selective uptake of lipoprotein-donated cholesterol. ; Professor and Chairman; University of Texas Sw Med Ctr/Dallas Dallas, TX 753909105 Timing: Fiscal Year 2002; Project Start 01-JUL-2002; Project End 30-JUN-2007 Summary: (provided by applicant) In this new project, our major focus is to understand how cholesterol and cell surface receptors involved in lipoprotein metabolism function together to transmit signals from the cell surface to the cell interior.